COMMON CAROTID ARTERY INTIMAL MEDIAL THICKNESS IN PATIENTS WITH A NORMAL LDL-CHOLESTEROL AND AN ELEVATED hsCRP Author Block: A Thakrar, L Noronha, A Peirce, D Brouillard, M MatangiKingston, Ontario Abstract:PURPOSE: Patients enrolled in the JUPITER trial had low and intermediate Framingham risk scores (FRS). Our own data indicates that 46% of low and 74% of intermediate FRS have abnormal carotid studies. We decided to assess the degree of carotid artery disease including common carotid artery (CCA) maximal intimal medial thickness (IMT) and severity of internal carotid artery (ICA) stenosis in our own patients enrolled in the JUPITER trial.METHODS: Patients enrolled in the JUPITER trial at two investigator sites were asked to undergo carotid duplex imaging. This was arranged after the JUPITER trial results had been presented and published. All carotid studies were interpreted using Intersocietal Commission for Accredited Vascular Laboratory (ICAVL) imaging and velocity criteria.RESULTS: The results are shown in Table 1. Only one of the 28 patients had a completely normal carotid study with no ICA stenosis and a maximal CCA IMT of 0.9mm bilaterally. The remainder had either IMT thickening, or an ICA stenosis by ICAVL imaging and velocity criteria or both.CONCLUSIONS: Although this is a small number of JUPITER patients, it is clear that most patients we enrolled had very abnormal carotid studies. It brings up the question as to whether or not JUPITER patients are really low and intermediate risk. Certainly based on these results of our JUPITER patients, they were mostly high risk based on their carotid disease. Table 1. Normal IMT abnormal CCA IMT abormals 1-39% 40-59% 60-79% 80-95% CCA IMT (1-95%) R) Carotid 1 6 1.05+/-0.21 18 2 1 0 1.08+/-0.29 L) Carotid 1 5 1.14+/-0.27 21 0 0 1 1.22+/-0.64 :Author Disclosure Information: A. Thakrar, None; L. Noronha, None; A. Peirce, None; D. Brouillard, None; M. Matangi, None.