The Amount of Microalbuminuria Increases with Diminishing Blood Pressure Control
Author(s): Etemadi B.A.1, Armstriong D.W.2, Brouillard D.2, Nault M.2, Matangi M.F.2Institute(s): 1Queens University, Kingston, Canada, 2Kingston Heart Clinic, Kingston, Canada
Purpose: Increasing microalbuminuria is associated with increased cardiovascular risk. Our purpose was to determine the differences in degrees of microalbuminuria in patients with different hypertensive phenotypes as determined by 24hr ambulatory blood pressure monitoring (ABPM).
Methods: BLOODfile and 24hrBPfile, the biochemical and ABPM modules of CARDIOfile, our cardiology database was searched for all patients who had both an ABPM and measurement of microalbuminuria within 90 days of each other. Microalbuminuria was defined as < 400mg/l in a urine specimen. There were 535 patients who fulfilled these criteria and were used in this analysis. One way ANOVA was used to determine significance between all means and Tukey-Kramer comparisons test between groups.
Results: Of the 535 Patients, 33 were normotensive on no drugs, (NT), 23 had white coatsyndrome (WCS), 52 were newly diagnosed hypertensives (NHT), 98 were controlledhypertensives, (CHT) 11, had masked hypertension (MHT), 137 were controlled hypertensives with white coat effect, (WCE) and 181 were uncontrolled hypertensives (UHT) on treatment. Results are presented as mean ± sem.
Conclusions: It is clear from these data that patients with uncontrolled hypertension havesignificantly more microalbuminuria. The MHT and WCE data are interesting but did not reach statistical significance.[Results]